Washington [US]April 16 (ANI): A team of researchers from the American Chemical Society augmented a procedure in lab animals by coating an implant with a laser-activated dye that kills cells that produce the hormone ghrelin. hunger.
According to the researchers, with further development, the simple procedure could become a new type of minimally invasive treatment to help obese patients lose weight.
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The results of the study have been published in the journal “ACS Applied Materials & Interfaces”.
Implants can be inserted into the stomach through the mouth after local anesthesia. In 2019, Hwoon-Yong Jung, Jung-Hoon Park and their colleagues designed a new type of implant.
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The “intragastric satiety-inducing device” (ISD) consists of a stent – which lodges in the lower esophagus – attached to a disc that sits in the opening of the stomach. The disc has a hole in the center to allow food to pass through.
Tests on pigs showed that ISD reduced food intake and weight gain by improving feelings of fullness and reducing levels of ghrelin, which is produced by cells near the top of the stomach. But the device caused complications, including acid reflux and migration into the stomach.
In their latest project, Jung, Park, Kun Na and their colleagues wanted to find out if they could suppress ghrelin even further by coating the ISD’s disk with a compound that, with a blast of laser light, could kill some of the ghrelin-producing cells. . The implant could then be removed to avoid the side effects associated with the initial conception.
In this preliminary study, the team coated the ISDs with methylene blue – an FDA-approved drug – and then placed them in the stomachs of young pigs. When exposed to laser light, the coating releases singlet oxygen, an energized form of oxygen that kills nearby ghrelin-producing cells in pigs’ stomachs, then quickly disappears.
After one week, the treatment halved ghrelin levels and body weight gain compared to an untreated pig, although these differences diminished over the following weeks unless the light treatment was repeated. (ANI)
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